Minigames are a recognition of the problem, but aren't really a solution. All you are really is a good card catalog of crafting recipes.Ĭrafting minigames. Second, your uniqueness is going to be fleeting, as other smiths do the same content, and get the same recipes. You shouldn't need to join a raiding guild, and beat the bosses to have a competitive smith. The problem is you can't have a real profession of crafting if you need to do lots of regular PvE content to progress as one. But it typically involves doing something other than crafting to aquire, grinding reputation, or participating in certain other PvE content (Raid Drop Recipes). This sounds good at first, in that it provides something the crafter can do to differentiate themselves. There have been many small attempts at improving the situation, but most have been superficial, or even undermined the concept of independent crafters.
Once the economy reaches maturity, it typically ends up just being another grind, perhaps with a perk at the end. The problem is that most games just tack on a crafting system as an add on to the rest of the game, its almost never fully integrated. You would have players that devote themselves to smithing, not as an aside to regular play, but as the core thing they do in the game. What I want is a system where there are a handful of grand master sword smiths, who have products that vary, are better than any other sword available in their own ways, and players should seek out them out for custom, high end gear. You have the best raiding guilds, and the best PvP pros, you would also have the best swordsmith (or maybe more narrowly, the best rapier smith). Through hard work, that swordsmith should be able to specialize, and improve their trade, to the point that their swords are specifically sought out as the best you can get. Lets start with a swordsmith, while applicable to fantasy settings, the same concepts would apply to any crafter of finished good. All rights reserved.I don't have a solution, but let me start by outlining a vision for what crating could be. This study is the first report to study the anti-fibrosis effects of CS on the basis of combining a metabonomics and network pharmacology approaches, and it may be a potentially powerful tool to study the efficacy and mechanisms of traditional Chinese folk medicines.Ĭarbon tetrachloride Corydalis saxicola bunting Liver fibrosis Metabonomics(1)H-NMR Network pharmacology.Ĭopyright © 2018 Elsevier B.V. Chelerythrine and sanguinarine were the potential active compounds in CS for treating liver fibrosis through regulating ALT activity. Subsequently, 5 target proteins, which are the intersection of potential CS targets and liver fibrosis targets, indicated that CS has potential anti-fibrosis effects through regulating alanine aminotransferase (ALT) activity, the farnesoid X receptor (FXR), cyclooxygenase-2 (COX-2), matrix metalloproteinase-1 (MMP-1) and angiotensinogen. Additionally, 157 potential targets of CS and 265 targets of liver fibrosis were identified by means of network pharmacology. As a result, lipids, leucine, alanine, acetate, O-acetyl-glycoprotein and creatine were significantly restored after CS treatment, which regulated valine, leucine and isoleucine metabolism arginine and proline metabolism lipid metabolism and pyruvate metabolism. Metabolic profiling by means of partial least squares-discriminate analysis (PLS-DA) indicated that the metabolic perturbation caused by CCl 4 was reduced after CS treatment. Metabonomic study of serum biochemical changes by carbon tetrachloride (CCl 4)-induced liver fibrosis in rats after CS treatment were performed using 1H-NMR analysis. In this work, an integrated approach combining proton nuclear magnetic resonance ( 1H-NMR)-based metabonomics and network pharmacology was adopted to elucidate the anti-fibrosis mechanism of CS. However, the exact mechanism of how it cures liver fibrosis requires further elucidation.
Corydalis saxicola Bunting (CS), a type of traditional Chinese folk medicine, has been reported to have hepatoprotective effects on the liver. Furthermore, prolonged unresolved liver fibrosis may gradually progress to cirrhosis, and eventually evolve into hepatocellular carcinoma (HCC). Liver fibrosis is a common consequence of chronic liver diseases resulting from multiple etiologies.